October 15, 2018

Assessing Probability

There are a number of methods used to assess the probability of an event resulting from medication administration. The Naranjo Scale is perhaps the most common […]
September 24, 2018

Revisiting Once Daily Dosing

  Recently we were asked to evaluate a patient  who was administered gentamicin 440 mg IV q24 hr. The patient received 5 doses prior to obtaining […]
August 27, 2018

First Dose Levels

In an effort to achieve accuracy, oftentimes clinicians are hesitant to check first dose peak and trough levels for aminoglycosides. The tendency is to obtain peak […]
August 13, 2018

Pharmacokinetic Dosing Errors

Medication errors associated with pharmacokinetics can sometimes get overlooked. Oftentimes, dosing errors occur but may go unreported. This can be especially true when dealing with aminoglycosides. […]
August 6, 2018

Errors with Volume of Distribution

In my experiences with dosing, antibiotics tend to offer the greatest challenge, especially in septic patients. The reason this is a challenge is because septic patients […]
July 30, 2018

Errors with Half Life Determination

Calculating elimination rate constants and half lives can be challenging in patients that are unstable. For drugs that are eliminated renally, it is important to ensure […]